Whether it’s creating a bioprocess from scratch or optimising your existing protocols, we have a bioprocessing solution that suits your needs.
Which parameters should be considered for bioprocess development?
Typically, Bioprocess development relies on finding a balance between dynamic parameters such as:
- Temperature
- Oxygen level
- pH
- Osmolarity
- Agitation
- Nutrient supply
- Waste removal
We help cultivated meat producers find the window of operation with each of these parameters. Our goal is to develop as efficient a bioprocess as possible.
What does bioprocess development involve?
We use a Design of Experiments approach with small-scale, high-throughput parallel bioreactor systems. This enables us to test multiple parameters at the same time. We also employ in-depth analytics to ensure a high-quality product is maintained in the window of operation.
A common mistake in bioprocess development is focusing only on what works, rather than discovering where the point of failure lies for each parameter. Understanding the ranges in which cells grow – and, importantly, the ranges in which they do not – inform the optimisation stages of bioprocess development as well as the translation to scale-up.
What method of bioprocessing is best?
This depends entirely on the client’s business strategy and their cultivated meat product. Batch or fed-batch fermentations are cost-effective and simple, however, cells require more nutrients as they grow and often produce inhibitory metabolites, impacting the yield.
In order to make cultivated meat cost-effective, we need to look at technologies like perfusion, such as those employed in hollow fibre bioreactors. These can separate waste from fresh nutrients, maximise yields, and ultimately bring down the costs of the final product.
